Installing a custom ROM on a custom kernel

Hi all,

I have a question regarding flashing a custom ROM on my phone. My S5 is running Lollipop with the original stock Touchwiz (tailored to my phone provider in Europe) and I have flashed a custom kernel on it. Now, I want to flash a custom ROM to get Marshmallow.

Is it safe to flash a custom ROM on a custom kernel or do I have to go back to the original kernel?

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